The Rockies are 29-13 against the Brewers at Coors Field, their best home record against any opponent.
"I'm really excited about this series and hopefully I'll get to play, because I remember I did great last time and hopefully I'll get to do the same thing," said center fielder Carlos Gonzalez, who is nursing a sore left knee but could play Saturday. "It's good to know there's a team coming that you hit really well against."
Colorado has swept six home series against Milwaukee and is 1-2 against the Brewers this year, as the teams met in their first series of the season.
In that three-game series, Gonzalez went 8-for-15 with four runs and two RBIs. First baseman Todd Helton went 5-for-10 and is a .317 career hitter against the Brewers. Ryan Spilborghs, starting in center field Friday, is a career .367 hitter against Milwaukee.
"This is going to have to be a collective effort," Rockies manager Jim Tracy said. "But it's not something we're unfamiliar with. Collective effort, in my opinion, is what has made us good for a period of time and it's going to have to continue."