Helton, who went 2-for-18 over the first six games of the road trip and grounded out in his first at-bat Friday, drove in runs in his second and third at-bats against D-backs starter Brandon Webb. The second, on a single in the fifth inning, was the 1,000th RBI of his career.
Those were the first two RBIs of the season for Helton, who entered 2007 ranked 38th among active players in career RBIs. He became the 250th player to reach quadruple figures in the category.
"It's a large number," Helton said. "There's no denying I'm proud to get there and hoping to get some more."
Rockies manager Clint Hurdle said, "He's a great player and he's a great hitter. To knock down that milestone has got to feel pretty special."
Thomas Harding is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.