De La Rosa, who is in his fifth season with the Rockies, made just 10 starts a year ago before having Tommy John surgery on his left elbow.
"It will be to the tune of four innings and 60 pitches," Rockies manager Jim Tracy said.
Outman is working his way back after an oblique strain sustained earlier this month, after the 27-year-old reliever got food poisoning that resulted in a significant amount of vomiting.
"His will be a more controlled circumstance," Tracy said. "His is more of a batting practice-type situation than it is actually pitching in the game like Jorge's going to do."