The Rockies said Rosario has a low-grade left ankle sprain and is listed as day-to-day.
Rockies left-hander Drew Pomeranz bounced his 0-1 pitch to Yonder Alonzo. Rosario couldn't keep the ball in front of him, and awkwardly rolled to his left and tumbled. The wild pitch allowed Yasmani Grandal to move from second base to third.
Rosario was able to hop up and retrieve the ball, but left the game after trainers tended to him briefly on the field. Veteran catcher Ramon Hernandez replaced him.
Rosario, 23, came into the game hitting .255 and leading NL rookies in home runs with 15 and RBIs with 39.
Thomas Harding is a reporter for MLB.com. Read his blog, Hardball in the Rockies, and follow him on Twitter @harding_at_mlb. This story was not subject to the approval of Major League Baseball or its clubs.