"It means everybody's getting their timing down and seeing the ball better," Nelson said. "You see a guy in front of you get a hit and get next guy get a hit, you don't want to be the one to roll over on a ground ball."
Nelson struggled with the timing of his leg kick early in camp.
"I've felt pretty good the last four or five days," he said.
Nelson, who hit .301 last season in his first year as the primary starter at third base but is trying to fend off a challenge from prospect Nolan Arenado, parked a three-run homer to left in the big second inning off Indians starter Brett Myers, who yielded 10 runs on 14 hits in 3 1/3 innings.
Cuddyer's first homer was a leadoff shot in the fifth off Indians reliever David Huff.
Rutledge doubled twice on a night when he improved his batting average from .222 to .286. Rosario had three singles and a double, Dexter Fowler's three hits included a double. Nelson's three hits improved his average from .231 to .273.
Rockies starter Jeff Francis threw 98 pitches in five innings and gave up three runs on nine hits. Francis completed strong Cactus League work (3-1, 2.70 ERA) by striking out three and walking no one.
Francis was tested in the bottom of the fourth and top of the fifth innings. He scored from first, and had to slide to do it, on Fowler's fourth-inning double, then pitched a quiet fifth.
"I was happy in the fifth inning, coming out and having a quick inning after a long inning," Francis said. "I did some good things, made some adjustments."
The Indians' Jason Kipnis drove in two runs.
Rockies left fielder Carlos Gonzalez left the game in the fourth because of allergies, the team reported.
Up next: Right-hander Jon Garland, who pitched well for the Mariners but found no room in the rotation, will make his Rockies debut Tuesday at 8:05 p.m. MT against the Dodgers at Glendale, Ariz., in MLB.TV's Free Game of the Day.