Betancourt has already had two stints on the disabled list this season, so Weiss is confident that Brothers and the rest of the bullpen can make a smoother than normal transition.
"I love Rex in the game, whether it's the seventh, eighth or ninth inning," Weiss said Friday before the Rockies' game against the Marlins. "It doesn't matter to me exactly where he pitches. He's going to protect the lead regardless of the inning. I think he's one of the more talented left-handed relievers in the game."
Weiss acknowledged that Betancourt's latest setback will force him to alter his normal approach late in games.
"We've got some options, but we might have to be a little more creative than when Raffy's around," Weiss said. "We might give our starters a little longer leash, but you still want to have the mentality to protect our starters, but we've also got to use common sense, too. There's times when you have to protect the bullpen and manage accordingly."
Brothers was 2-0 with a 1.51 ERA and 11 saves in 12 chances entering the three-game series at Marlins Park.
Adam Ottavino and Brothers each pitched a 1-2-3 inning with two strikeouts in Friday's 3-2 win over the Marlins.
Steve Dorsey is a contributor to MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.