The Rockies left-hander, one of the anchors of a much-improved rotation, has been pitching through a sore left thumb since June. He also battled pain in his index and middle fingers in a Sept. 10 start against the Giants, but lasted just two innings and hasn't pitched since.
As recently as Monday, when he played catch, De La Rosa was hopeful that he could make his Saturday start.
McHugh will start in place of the southpaw as he did Monday, when he allowed one run over five innings against the Cardinals.
After missing this start, De La Rosa likely won't get more than one more start this year. He's having one of the best seasons of his career; his 16 wins tie a career high and his 3.49 ERA is the lowest of his career
Ian McCue is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.