"Guys swung the bats well against Blanton, who's a good pitcher," Rockies manager Walt Weiss said. "It's a good sign the way we swung the bats."
Tulowitzki crushed the first offering he saw for a solo homer in the first and followed two innings later with a two-run blast for his first two homers of the spring.
"He's one of the best in the game," said Weiss. "You saw the game today. Just one of the best there is."
Rockies catcher Michael McKenry added a solo homer in the third, and second baseman Josh Rutledge hit a two-run shot in the fourth to end Blanton's outing after 3 1/3 innings. The veteran allowed seven runs on eight hits and a walk.
Rockies left-hander Jorge De La Rosa rebounded from a subpar Cactus League opener by allowing one run on three hits and striking out two over three innings.
Left fielder Tim Wheeler added an RBI double for Colorado.