After consecutive singles to begin the sixth, a pitch from Kluber sailed too far inside on Arenado, who was struck on the hand. Arenado -- with a pair of doubles in the game to boost his Cactus League average to .341 in 16 contests -- was pulled from the game.
The Rockies announced at the park that Arenado has a bone contusion, and X-ray's taken later at the club's complex came back negative, leaving Arenado's status as day to day.
Justin Morneau followed with a two-run single, Josh Rutledge added a run-scoring single and Paul Janish doubled home another run to push Colorado in front, 7-6. In the fifth inning, Jordan Pacheco drilled a 1-2 pitch from Kluber deep to left field for a two-run home run for the Rockies.
Kluber, who is slated to begin the season as the Tribe's No. 2 starter, was charged with seven runs on 11 hits in six innings, ending with one strikeout and no walks in the effort.
For the Indians, left fielder Michael Brantley continued his offensive tear. Brantley contributed a run-scoring double in the fourth inning and added a two-run triple in the fifth, giving him nine extra-base hits and 10 RBIs in 13 games this spring.
Rockies pitcher Jordan Lyles, who is competing for the fifth spot in Colordo's rotation, finished the afternoon with five runs allowed (two earned) on five hits in 4 2/3 innings. Lyles struck out three and walked three.
The Indians broke through for four runs in the fifth inning, during which Morneau misplayed a sharply hit grounder from Asdrubal Cabrera for an error that allowed a run to score. Nick Swisher followed with an RBI double to the wall in right-center, and then Brantley delivered his triple to give the Indians a 5-2 advantage.
In the sixth inning, utility man Mike Aviles belted a leadoff home run against Rockies reliever Adam Ottavino.
Colorado's Tim Wheeler hit his fourth homer of the spring in the eighth inning, a three-run shot off Indians lefty Josh Outman.
Up next: Right-hander Tyler Chatwood will start, and veteran relievers Matt Belisle, LaTroy Hawkins, Wilton Lopez and Adam Ottavino are lined up to pitch on Sunday against the White Sox at Salt River Fields at Talking Stick at 1:10 p.m, live on MLB.TV.