Tulowitzki left Sunday's 2-0 loss to the Dodgers in the fifth inning with a strain in the right quad and is listed as day-to-day. Rockies head athletic trainer Keith Dugger said it's possible the Rockies will order an MRI.
Tulowitzki has a history of quad problems. He missed 46 games in 2008 with a tear of the quadriceps ligament and missed a month in the Minors with a quad strain shortly after being selected seventh overall in 2005. But those issues were with the left quad.
"So if someone doesn't ask me if it's the same thing as last time; it's the same spot, but a different leg," Tulowtizki said.
Tulowitzki said he does not believe the injury is at the level it was with the 2008 injury, "but you never know."
Tulowitzki was injured attempting a double-play relay throw. The Dodgers' Jamey Carroll grounded to the mound, where Ubaldo Jimenez wheeled to throw to second. Tulowitzki avoided the sliding Blake DeWitt, but his throw was not in time.
Tulowitzki moved awkwardly on the play, partly because he was screened on the throw by second-base umpire Gary Darling, who was moving into position to see the play at second.
"With Jimenez on a comebacker, out of anybody on the team, you really try to gather your feet and see the ball because the throw is so hard," Tulowitzki said. "The umpire, I don't know what happened. He was crossing, so I was sitting there blind, with Jimenez throwing. You don't know what's going to happen. I finally saw the ball and took an awkward step."
After the action stopped, Dugger and Rockies manager Jim Tracy visited with Tulowitzki, who attempted to run on the infield dirt before being removed.
In 2008, Tulowitzki stayed in the game after tweaking the muscle, then suffered a far greater injury.
"It was kind of precautionary to come out, but at the same time I think it was the right decision," he said.
Tulowitzki was 1-for-2 with a bunt single and a strikeout. For the season, he is batting .311 with one home run and 14 RBIs.
Since the 2008 injury, Tulowitzki has developed a pregame routine and overall fitness plans that combat leg muscle tightness.
Clint Barmes move from second base to shortstop and Melvin Mora entered at second after Sunday's injury.